This article is copyrighted by GreenMedInfo LLC, 2013, Some features are currently member only features. El almacenamiento o acceso tcnico es estrictamente necesario para el propsito legtimo de permitir el uso de un servicio especfico explcitamente solicitado por el abonado o usuario, o con el nico propsito de llevar a cabo la transmisin de una comunicacin a travs de una red de comunicaciones electrnicas. The very concept of "marketing" is at odds with the real nature of these materials, which has to do with the protection and expansion of our nature and potential. Indeed, research indicates that hypothyroid patients treated with T4 replacement, that is sufficient to maintain a normal serum TSH, actually have serum free T4 that is higher than in untreated normal patients and may not result in appropriately normal serum free T3 concentrations. With the recent announcement by a National Cancer Institute commissioned expert panel that a variety of so-called 'indolent' neoplasms such as ductal carcinoma in situ (DCIS) and high-grade prostatic intraepithelial neoplasia (HGPIN), formerly understood to be forms of breast and prostate cancers, respectively, should be renamed to reflect their intrinsic benignity, a veritable sea change is occurring within the conventional medical establishment. At GreenMedInfo.com, we have indexed plenty of peer-reviewed research on over 30 natural substances, including nutrients and minerals, which may help to resolve low thyroid function, and conversely, over 30 unnatural substances, e.g. Assessment of oxidative stress and its balance has not been taken into consideration up to now as it should be. Endocrinology 2008, 149:22412250. Comp Biochem Physiol C Toxicol Pharmacol 2002, 133:475481. Considering that the population in Italy is about 60 million people and the sales of LT4 in the country in 2010 were 17.69 million boxes (+ 6% Vs 2009), hypothyroidism, which is the main reason for the prescription, should be a real national concern (almost 0.7 boxes/women/year). Thus, I am monitored carefully. It does not necessarily imply one thing caused the other. But that's just me. The authors also cite animal experimental research which has shown that T4 increases the oxidative stress[6] and spontaneous pulmonary metastases in mice. In 2011 I switched docs and was put on Armour as he told me Synthroid and the like are poison and they do not work. In 2020 alone, there were more than 2.2 million new cases and 1.8 million deaths from lung cancer globally. (February 2002). Physician/Author on Facebook. They then correlated drug sales with cancers, eliminating the contribution of age and smoking for lung cancer risk. However, I'm learning from science writer friends, researchers, and medical professionals that (1) some studies are better designed and carried out than others, and (2) some journalists are more careful about drawing conclusions and writing sensational headlines than others. When a high-risk patient presents with one or more lung nodules, the path ahead and next steps seems obvious. Gestionar el consentimiento de las cookies. A total of 425 inpatients with malignant tumors were treated with ICIs at PUMCH during the study period. In discussing their findings, the authors noted that they could not exclude the possibility that the condition of hypothyroidism could favor the development of lung cancer. Epub 2013 Mar 28. http://www.greenmedinfo.com/blog/study-millions-treated-hypothyroidism-risk-l Study: Millions Treated for Hypothyroidism At Risk for Lung Cancer, Iodine Supplementation Support by VWT Team. The relationship between levothyroxine use and cancer risk is largely underdetermined. 2013 May ;98(5):1982-90. Furthermore, the geometric expansion of hypothyroidism cases in the past decade only thinly conceals an agenda to promote the synthetic form of T4 known as levothyroxine sodium (trade name Synthroid), since with each new 'disease' case the patient is converted into a lifelong customer. Join the Patient & Caregiver Network. [4] Ratcliffe JG, Stack BH, Burt RW, Radcliffe WA, Spilg WG, Cuthbert J, Kennedy RS: Thyroid function in lung cancer. If the results show that TSH is high and T-4 is low, then the diagnosis . This discussion has been closed to comments. Oops I have just bought my first jar of marmalade in over ten years! [4] Ratcliffe JG, Stack BH, Burt RW, Radcliffe WA, Spilg WG, Cuthbert J, Kennedy RS: Thyroid function in lung cancer. They then correlated drug sales with cancers, eliminating the contribution of age and smoking for lung cancer risk. Or, if fluoride, mercury, or any number of xenobiotic chemicals in the environment requiring selenium-dependent glutathione-mediated detoxification is causing the "low thyroid," why call chemical poisoning "hypothyroidism"? Levothyroxine is a widely prescribed medication for the treatment of an underactive thyroid. It was the therapist that I went to that referred me to a specialist who ran the correct tests. hyperthyroidism. 2004 Jun;9(2):157-79. Sayer Ji is the founder ofGreenmedinfo.com, a reviewer at theInternational Journal of Human Nutrition and Functional Medicine,Co-founder and CEO of Systome Biomed, Vice Chairman of the Board of theNational Health Federation, and SteeringCommittee Memberof the Global Non-GMO Foundation. Based just on this article, I think the study's conclusion that Synthroid may cause an increase in lung cancer risk is premature. SayerJiis founder ofGreenmedinfo.com, a reviewer at theInternational Journal of Human Nutrition and Functional Medicine,Co-founder and CEO of Systome Biomed, Vice Chairman of the Board of theNational Health Federation, SteeringCommittee Memberof the Global Non-GMO Foundation. [8] van Doorn J, Roelfsema F, van der Heide D: Concentration of thyroxine and 3,5,3-triiodotyronine in several rat tissue in vivo: the effect of hypothyroidism. undefined will no longer be visible to you including posts, replies, and photos. [7] They also elaborate on a mechanism of T4-induced lung tissue toxicity: "[I]n rats lung the deiodination of LT4 is the lowest compared to all the other tissues. There is also the very real possibility that T4 will not only not properly interact with thyroxine cellular receptors, but will block out what remaining natural levothyroxine the thyroid is still producing (and whose conformational state is far more health-promoting), essentially acting as an endocrine disrupter at the very moment that it is acting as intended as a TSH suppressor. This T4 blocking/endocrine-disrupting property of the synthetic form would also activate a negative feedback loop within the endocrine system, further suppressing remaining thyroid function, and resulting in the atrophy of the compromised thyroid, a iatrogenic self-fulfilling prophecy if you will. PMID: 15253676. Is that what releases free radicals? 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J Exp Biol 2010, 213:28992911. It looks at correlations, as if they had any merit on their own. Overtreatment, of course, is the hallmark danger of overdiagnosis. Why not simply call it selenium deficiency? View the data on GreenMedInfos Hypothyroidism Research page. Find how some diseases can be healed with alternative medicine, and share your experience with Is Drug-Based Medicine a Form of Human Sacrifice? Symptoms can include fatigue, shortness of breath with exercise, and decreased ability to exercise. Yes, lung cancer patients can have these symptoms, but so do patients who have other cancers. Forgot account? The authors expanded on their findings further: "However, the impression we get from our experience in epidemiological studies monitoring[12] is that this drug should be prescribed more cautiously. [12] Cesarone MR, Belcaro G, Nicolaides AN, Incandela L, De Sanctis MT, Barsotti A: San Valentino epidemiologic project. Ultimately, this latest Italian study is bringing to our attention one of what is likely a wide range of unintended, adverse health effects associated with the overdiagnosis and subsequent overtreatment of hypothyroidism, and the underlying failure of the conventional, largely drug-based paradigm to comprehend the causes and real solutions of disease and human suffering. Non-ASPS articles which could be relevant. [8] This means that the amount of LT4 reaching the lungs following an external supplementation cannot to be transformed into LT3 as in the other tissues, and make lungs very vulnerable to possible toxic effects of LT4. [11] Wan J, Chai H, Yu Z, Ge W, Kang N, Xia W, Che Y: H1F-1 on angiogenic potential in human small cell carcinoma. Nanosized aluminum being sprayed in the atmosphere CDC Admits as Many as 30 Million Americans Could b Why Turmeric May Be the Diseased Liver's Best Friend. Whereas a patient who had suboptimal thyroid function, but did not have noticeable symptoms, is suddenly given pharmacological doses of synthetic T4 and suddenly experiences the wide range of acute, adverse health effects associated with a now hyperactive and/or increasingly disrupted thyroid, as a result. Post author By ; Post date jaripeo hillsboro oregon 2021; what task do they have at camp westerbork on millions treated for hypothyroidism at risk for lung cancer on millions treated for hypothyroidism at risk for lung cancer Currently, the best practical approach is to base treatment decisions on the degree of TSH elevation, thyroid autoimmunity, and associated comorbidities. Oops, I just saw that I posted the same article. I am having a lot of trouble making any sense of this study. Could be another marmalade how would we know? Correlation is when two things seem to happen at the same time, in the same place, and/or in the same population. That's all. "A new study has uncovered a link between the synthetic thyroid hormone (trade name Synthroid) used to treat millions diagnosed with hypothyroidism and lung cancer, bringing to the forefront the harmful role that overdiagnosis and overtreatment plays in nutritional deficiency and chemical exposure related 'diseases.' In discussing their findings, the authors noted that they could not exclude the possibility that the condition of hypothyroidism could favor the development of lung cancer. weight loss, anorexia) was made many years ago together with an over production of both T4 and T3. El almacenamiento o acceso tcnico es necesario para crear perfiles de usuario para enviar publicidad, o para rastrear al usuario en una web o en varias web con fines de marketing similares. Hypothyroidism results from low levels of thyroid hormone with varied etiology and manifestations. Heart problems. Log In. A new study has uncovered a link between the synthetic thyroid hormone (trade name Synthroid) used to treat millions diagnosed with hypothyroidism and lung cancer, bringing to the forefront the harmful role that overdiagnosis and overtreatment plays in nutritional deficiency and chemical exposure related 'diseases.' [2] Meng R, Tang HY, Westfall J, London D, Cao JH, Mousa SA, Luidens M, Hercbergs A, Davis FB, Davis PJ, et al: Crosstalk between integrin v3 and estrogen receptor- is involved in thyroid hormone-induced proliferation in human lung carcinoma cells. Breast cancer has surpassed lung cancer as the most commonly diagnosed cancer worldwide, according to GLOBOCAN. Thank you for bringing it to our attention. [13] Hollowell JG, Staehling NW, Flanders WD, et al. May be of interest: Study: Millions Treated for Hypothyroidism At Risk for, Non-small cell lung cancer - Adenocarcinoma, Non-small cell lung cancer - Squamous cell, Top 5 Questions to Ask Your Lung Cancer Doctor, Patient & Caregiver Network Member Resources, Not A Member Yet? Thyroid disease is a major public health concern worldwide. Study: Millions Treated for Hypothyroidism At Risk of Lung Cancer. Patients with incomplete information (n = 127), preexisting hypothyroidism or levothyroxine replacement before initiation of ICI therapy (n = 11), or other factors known to contribute to thyroid dysfunction after immunotherapy (n = 17) were excluded (Fig. Respiratory system Hypothyroidism weakens the respiratory muscles and decreases lung function. Never delay seeking advice or dialling emergency services because of something that you have read on HealthUnlocked. Different strokes for different folks for sure! Garlic Beats Drug in Detoxifying Lead Safely From How Yoga and Acupuncture Enhance HealthNew Resear Health Nuts: Seeds And Nuts You Should Eat Every Day. Not what people like me are saying. In the United States, autoimmune thyroid disease (Hashimoto thyroiditis) is the most common cause of hypothyroidism, but globally lack of iodine in the diet is the most common cause. [12] Cesarone MR, Belcaro G, Nicolaides AN, Incandela L, De Sanctis MT, Barsotti A: San Valentino epidemiologic project. (31) 3351-3382 | 3351-3272 | 3351-3141 | 3351-3371. location of blind frog ranch associe-se. Now, I will bring it to the attention of my Endocrinologist. 1 The number of individuals with thyroid disorders is expected to continue to grow, having reached approximately 750 million globally in 2012. By rejecting non-essential cookies, Reddit may still use certain cookies to ensure the proper functionality of our platform. Very interesting article, thank you for sharing. Baked or Fried avocado fries [Vegetarian]. Untreated hypothyroidism increases morbidity and mortality. However, they pointed out that the opposite was recently described, and that "hypothyroidism reduces theaggressiveness of some cancers because of the presence of thyroid hormone receptors oncancer cells, and spontaneous hypothyroidism may delay onset or reduce aggressiveness ofcancers."[1]. J Endocrinol Invest. Levothyroxine therapy and serum free thyroxine and free triiodothyronine concentrations. ", Cure Alveolar Soft Part Sarcoma International, COMPLETED - Dana Farber Vaccine Clinical Trial (GVAX), Axitinib and Pembrolizumab (Keytruda) in Miami, US, TECENTRIQ (atezolizumab) by Genentech, Treatment of Non-Resectable Primary Tumor, Immune checkpoint inhibitors ICI (PD-1 and PD-L1 targeting drugs), Toxicity, problems and potentiation strategies, Treatment response criteria and evaluation/scanning problems/rare cases, treatment discontinuation/re-treatment, Side effects/complications of the local ablations, High intensity focused ultrasound (HIFU), Study: Millions Treated for Hypothyroidism At Risk for Lung Cancer, http://www.greenmedinfo.com/blog/study- ng-cancers. 'A new Italian study published in the journal Reproductive Biology and Endocrinology titled, "Levothyroxine and lung cancer in females: the importance of oxidative stress," has raised a concerning possibility: levothyroxine (T4), one of the world's most commonly prescribed forms of hormone replacement, may be raising the risk of lung cancer in millions of men and women being treated for low thyroid function (hypothyroidism). Furthermore, the geometric expansion of hypothyroidism cases in the past decade only thinly conceals an agenda to promote the synthetic form of T4 known as levothyroxine sodium (trade name Synthroid), since with each new disease case the patient is converted into a lifelong customer. [8] van Doorn J, Roelfsema F, van der Heide D: Concentration of thyroxine and 3,5,3'-triiodotyronine in several rat tissue in vivo: the effect of hypothyroidism. I've been on synthroid for 20+ years, scary. As you know, I appreciate people posting links that help us learn more about lung cancer, too. [8] This means that the amount of LT4 reaching the lungs following an external supplementation cannot to be transformed into LT3 as in the other tissues, and make lungs very vulnerable to possible toxic effects of LT4. I'm just saying the evidence presented in this article isn't very strong, and more study is needed to show Synthroid causes lung cancer. Link posted. The authors delved deeper into the reason why oxidative stress taking place during T4 treatment is particularly linked to lung cancer only: The hypothesis could be that in lungs the increase of hypoxia-induced factor (HIF-1) which is determined by T4 can make oxygen much more available, increasing locally the oxidative stress together with a dangerous angiogenesis stimulation. The omnipresent environmental contaminant perchlorate, an ingredient in jet fuel, is also a primary cause of hypothyroidism, but is almost never tested for by the conventional endocrinologists in their patient evaluations. Study: Millions Treated for Hypothyroidism At Risk for Lung Cancer J. Clin. The estimated 2.3 million new cases indicate that 1 in every 8 cancers diagnosed in . Cancer-related fatigue (CRF) is common in lung cancer survivors and can occur at any point in the care continuum. "Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III)", International Journal of Human Nutrition and Functional Medicine, Osteoporosis Is Scurvy of the Bone, Not Calcium Deficiency, 6 Bodily Tissues That Can Be Regenerated Through Nutrition, 7 Simple Ways to Unclog Your Arteries Naturally, Herbal Cream Clears 87.7% of HPV Cases Naturally, How WHOLE Turmeric Heals the Damaged Brain. I cried with joy when I found out there was something really wrong with me. Angiology 2000, 51:S65S68. [1] Hercbergs AH, Ashur-Fabian O, Garfield D: Thyroid hormone and cancer: clinical studies of hypothyroidism in oncology. Post In comparison, 62.4% of female and 37% of male . JavaScript is disabled. Eventually, the decline in thyroid hormone production can result in any of the following: Fatigue and sluggishness. Most of the time, doctors tell patients treated with LT4 that any side effects will be temporary and almost ineluctable, and are usually dealt with through dose reduction. ', Study: Millions Treated for Hypothyroidism At Risk for Lung Cancer. Sub-laboratory hypothyroidism and the empirical use of Armour thyroid.Altern Med Rev. Modern Medicine, Part I: How Healing Illness Becam Is your body getting too acidic? At GreenMedInfo.com, we have indexed plenty of peer-reviewed research on over 30 natural substances, including nutrients and minerals, which may help to resolve low thyroid function, and conversely, over 30 unnatural substances, e.g. [14] K A Woeber. However, they pointed out that the opposite was actually described, and that hypothyroidism reduces the aggressiveness of some cancers because of the presence of thyroid hormone receptors on cancer cells, and spontaneous hypothyroidism may delay onset or reduce aggressiveness of cancers.[1]. Also, what is oxidised stress??? Copyright 2008-2023 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM. Content on HealthUnlocked does not replace the relationship between you and doctors or other healthcare professionals nor the advice you receive from them. Note: Only a member of this blog may post a comment. Endocrinology 1985, 117:12011208. Objectives: To examine site-specific cancer incidence and mortality and to evaluate the radiation dose-response association after RAI treatment for hyperthyroidism. Those with the greatest risk of developing thyroid disorders are women who have a family history of the disease. Indeed, research indicates that hypothyroid patients treated with T4 replacement, that is sufficient to maintain a normal serum TSH, actually have serum free T4 that is higher than in untreated normal patients and may not result in appropriately normal serum free T3 concentrations. In an attempt to show causation, the article notes "patients with small cell carcinoma of the lung often present symptoms suggestive of hyperthyroidism (i.e. [5] Wawrzynska L, Sakowicz A, Rudzinski P, Langfort R, Kurzyna M: The conversion to triiodothyronine in the lung: comparison of activity of type I iodotironine 5' deiodinase in lung cancer with peripheral lung tissues. View the data on our Hypothyroidism Research page. [13] Hollowell JG, Staehling NW, Flanders WD. Marketed as superior to traditional glandular forms extracted from pigs (whose endocrine glands are far more bioidentical than any other animal we know of) due to the dose-to-dose standardization of the so-called active ingredient T4 versus the natural variations in hormone concentrations found in the real thing, which incidentally contains a wide range of additional hormones including T1, T2, T3, all of which are vitally important. It is worth reading. "Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III)". Data sources: The Medline and Cochrane Library electronic databases . Diagnosed 1/12 with lung cancer out of the blue. Correlation is not causation. Symptoms. BUT, this is the first I have heard of the potential risk of lung cancer in those who take Synthyroid. A place for patients and relatives. ", Orsomeone posts something about, say a diet or supplement and them some people think they are something it "Cures lung cancer.". weight loss, anorexia) was made many years ago together with an over production of both T4 and T3. (They noted that this age range corresponds to more than 80% of the consumers of the drug and to about 99% of all malignant cancers). One of the main drawbacks of administering T4 in isolation is the possibility that it will not convert adequately to T3, and will therefore 'back up' causing excessive T4 activity, i.e. This T4 blocking/endocrine-disrupting property of the synthetic form would also activate a negative feedback loop within the endocrine system, further suppressing remaining thyroid function, and resulting in the atrophy of the compromised thyroid, a iatrogenic 'self-fulfilling prophecy' if you will. I don't think so. I have no further scientific evidence. Another recently approved drug is tepotinib (Tepmetko). Clin Cancer Res 2011, 30:77. Why not simply call it selenium deficiency? video where the doc is talking about the study , i wlll link study and video below. So I will leave it as a simple thank you for passing this along. [7] They also elaborate on a mechanism of T4-induced lung tissue toxicity: [I]n rats lung the deiodination of LT4 is the lowest compared to all the other tissues. 'A new Italian study published in the journal Reproductive Biology and Endocrinology titled, "Levothyroxine and lung cancer in females: the importance of oxidative stress," has raised a concerning possibility: levothyroxine (T4), one of the world's most commonly prescribed forms of hormone replacement, may be raising the risk of lung cancer in millions of men and women being treated for low . El almacenamiento o acceso tcnico que se utiliza exclusivamente con fines estadsticos annimos. and our However, I do not believe it was out of the blue now. People read a study and think that someone like, perhaps me, is saying "it Causes lung cancer. Finally, they pointed out that T4, which is a synthetic form of thyroid hormone, might be avoided if T3 or the desiccated pig-derived form known as Armour Thyroid was used to control the oxidative-stress producing hydroperoxides. Compression of the trachea, which may be positional, can occur with nodular goiters and thyroid cancer, and the latter can metastasize to the lungs. Clin Cancer Res 2011, 30:77.
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